Obesity and Diabetes

Research from C.J. Wang and co-researchers in the area of obesity and diabetes published

Published in Obesity and Diabetes Week, August 18th, 2008

"Coinhibitory signals mediated via programmed death 1 (PD-1) receptor play a critical role in downregulating immune responses and in maintaining peripheral tolerance. Programmed death 1 ligand 1 (PD-L1), the interacting ligand for PD-1, widely expressed in many cell types, acts as a tissue-specific negative regulator of pathogenic T-cell responses," scientists in Taipei, Taiwan report.

"We investigated the protective potential of PD-L1 on autommume diabetes by transgenically overexpressing PD-L1 in pancreatic beta-cells in nonobese diabetic (NOD) mice. We established an insulin promoter-driven murine PD-L1 transgenic NOD mouse model to directly evaluate the protective...

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Source: Obesity and Diabetes Week (2008-08-18)

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