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Obesity

Study results from RIKEN provide new insights into obesity

Published in Obesity and Diabetes Week, August 25th, 2008

"Variations in the fat-mass and obesity-associated gene (FTO) are associated with the obesity phenotype in many Caucasian populations. This association with the obesity phenotype is not clear in the Japanese," scientists in Suehiro, Japan report.

"To investigate the relationship between the FTO gene and obesity in the Japanese, we genotyped single nucleotide polymorphisms (SNPs) in the FTO genes from severely obese subjects [n = 927, body mass index (BMI) >= 30 kg/m(2)] and normal-weight control subjects (n = 1,527, BMI < 25 kg/m(2)). A case-control association analysis revealed that 15 SNPs, including rs9939609 and rs1121980, in a linkage disequilibrium (LD)...

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