Life Sciences
Research results from P.K. Thanos and co-authors update knowledge of life sciences
Published in Obesity and Diabetes Week, September 1st, 2008
Research findings, 'Leptin receptor deficiency is associated with upregulation of cannabinoid 1 receptors in limbic brain regions,' are discussed in a new report. "Leptin receptor dysfunction results in overeating and obesity. Leptin regulates hypothalamic signaling that underlies the motivation to hyperphagia, but the interaction between leptin and cannabinoid signaling is poorly understood," investigators in the United States report.
"We evaluated the role of cannabinoid 1 receptors (CB(1)R) in overeating and the effects of food deprivation on CB(1)R in the brain. One-month-old Zucker rats were divided into unrestricted and restricted (fed 70% of unrestricted rats)...
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