According to recent research published in the journal Cell Metabolism, "The molecular mechanisms linking the stress of unfolded proteins in the-endoplasmic reticulum (ER stress) to glucoseintolerance in obese animals are poorly understood. In this study, enforced expression of a translation initiation factor 2 alpha (eIF2 alpha)-specific phosphatase, GADD34, was used to selectively compromise signaling in the eIF2(alpha P)-dependent arm of the ER unfolded protein response in liver of transgenic mice."
"The transgene resulted in lower liver glycogen levels and susceptibility to fasting hypoglycemia in lean mice and glucose tolerance and diminished hepatosteatosis...
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