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University of Tennessee at Knoxville

New findings explain genetic disorder's unique shift

Published in Obesity and Diabetes Week, September 8th, 2008

Findings reported in this month's issue of PLoS Biology give insight into the unique characteristics of the birth defect known as Prader-Willi Syndrome (PWS), and at the same time, may help explain the way that a certain type of gene is expressed in all humans.

The research by University of Tennessee, Knoxville, professor Francisco Ubeda finds that the amount of care a father gives to his child may cause a shift in the syndrome in which its symptoms, in essence, reverse themselves.

At birth, children with PWS experience great difficulty suckling and have very low weight. After they are weaned from their mothers, though, their appetites become...

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