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Physiology

New physiology study findings have been reported from Eli Lilly and Company

Published in Obesity and Diabetes Week, September 8th, 2008

New research, 'Activation of mesolimbic dopamine neurons during novel and daily limited access to palatable food is blocked by the opioid antagonist LY255582,' is the subject of a report. "An analog of the trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine series (LY255582) exhibits high in vitro binding affinity and antagonist potency for the mu-, delta-, and kappa-opioid receptors. In vivo, LY255582 exhibits potent effects in reducing food intake and body weight in several rodent models of obesity," scientists writing in the American Journal of Physiology - Regulatory, Integrative and Comparative Physiology report.

"In the present study, we evaluated the effects...

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