ETH Zurich/Swiss Federal Institute of Technology

Atomic structure of the mammalian 'fatty acid factory' determined

Published in Obesity and Diabetes Week, September 22nd, 2008

Mammalian fatty acid synthase is one of the most complex molecular synthetic machines in human cells. It is also a promising target for the development of anti-cancer and anti-obesity drugs and the treatment of metabolic disorders. Now researchers at ETH Zurich have determined the atomic structure of a mammalian fatty acid synthase. Their results have just been published in Science magazine.

Synthesis of fatty acids is a central cellular process that has been studied for many decades. Fatty acids are used in the cell as energy storage compounds, messenger molecules and building blocks for the cellular envelope. Until now, individual steps of this process have been...

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Source: Obesity and Diabetes Week (2008-09-22)

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