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Helmholtz Association of German Research Centres

Cortisol and fatty liver: Researchers find cause of severe metabolic disorders

Published in Obesity and Diabetes Week, September 22nd, 2008

A healthy body stores fat in the form of so-called triglycerides in specialized fatty tissue as an energy reserve. Under certain conditions the delicate balance of the lipid metabolism gets out of control and fat is accumulated in the liver, leading to the dreaded fatty liver. This increases the risk of many metabolic diseases, such as the metabolic syndrome known as "deadly quartet". This combination of fatty liver, obesity, diabetes and hypertension is regarded as the primary cause of life-threatening vascular events such as myocardial infarction and stroke.

It was still unknown which conditions cause the body to deposit fat in the liver. However, scientists knew that...

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