Life Sciences
Reports from University of Marburg advance knowledge in life sciences
Published in Obesity and Diabetes Week, September 22nd, 2008
A new study, 'Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: first evidence of polar overdominance in humans,' is now available. "DLK1 is part of the Notch signalling pathway that controls various developmental processes. A functional role for DLK1 in adipogenesis is suggested by several animal models," scientists writing in the European Journal of Human Genetics report.
"Interestingly, the DLK1 gene is imprinted in eutherian mammals. To study whether variations in DLK1 affect body weight in humans, we analysed 32 polymorphisms in a 109 kb genomic region encompassing DLK1 on human chromosome 14. In a study sample of 1025...
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