Johns Hopkins University Bloomberg School of Public Health
Researchers identify genes associated with increased gout risk
Published in Obesity and Diabetes Week, October 20th, 2008
A team of researchers from the United States and the Netherlands has identified mutations in three genes that are associated with high levels of uric acid in the blood, which is a risk factor for gout. The team developed a genetic risk score composed of the number of uric acid-increasing mutations that each person carries (0 to 6), which was associated with up to a 40-fold increased risk for developing gout when comparing persons at lowest and highest risk. The findings are published in the October 4 issue of The Lancet.
More than 3 million adults in the United States have gout. Gout is a painful inflammation of the joints, which can occur with a build-up of uric acid...
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