Research

Too many calories send the brain off kilter

Published in Obesity and Diabetes Week, October 20th, 2008

An overload of calories throws critical portions of the brain out of whack, reveals a study in the October 3rd issue of the journal Cell, a Cell Press publication. That response in the brain's hypothalamus—the "headquarters" for maintaining energy balance—can happen even in the absence of any weight gain, according to the new studies in mice.

The brain response involves a molecular player, called IKKb/NF-'B, which is known to drive metabolic inflammation in other body tissues. The discovery suggests that treatments designed to block this pathway in the brain might fight the ever-increasing spread of obesity and related diseases, including diabetes and heart disease....

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Source: Obesity and Diabetes Week (2008-10-20)

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