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Enzyme Research

Studies from Chiba University add new findings in the area of enzyme research

Published in Obesity and Diabetes Week, October 20th, 2008

New research, 'Matrix metalloproteinase-3 enhances the free fatty acids-induced VEGF expression in adipocytes through toll-like receptor 2,' is the subject of a report. According to a study from Chiba, Japan, "Infiltrated macrophages (Mphi) are believed to cause pathological changes in the surrounding adipocytes through the secretion of active molecules in visceral fat. Matrix metalloproteinase (MMP)-3 is secreted from Mphi, and enhances expression of the inflammatory cytokines through the activation of toll-like receptor (TLR) 2."

"Visceral adipocytes express high levels of vascular endothelial growth factor (VEGF), and the degree of visceral fat accumulation is...

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