Obesity and Diabetes Genetics
Scientists at Washington University, Department of Medicine report research in obesity and diabetes genetics
Published in Obesity and Diabetes Week, November 10th, 2008
Fresh data on obesity and diabetes are presented in the report 'Regulation of the PDK4 isozyme by the Rb-E2F1 complex.' "Loss of the transcription factor E2F1 elicits a complex metabolic phenotype in mice underscored by reduced adiposity and protection from high fat diet-induced diabetes. Here, we demonstrate that E2F1 directly regulates the gene encoding PDK4 (pyruvate dehydrogenase kinase 4), a key nutrient sensor and modulator of glucose homeostasis that is chronically elevated in obesity and diabetes and acutely induced under the metabolic stress of starvation or fasting," scientists in the United States report.
"We show that loss of E2F1 in vivo blunts PDK4...
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