Obesity and Diabetes
New obesity and diabetes study findings have been published by A. Anedda and colleagues
Published in Obesity and Diabetes Week, December 22nd, 2008
"Metformin inhibits respiration, and the decrease in cellular energy activate, the AMP-activated protein kinase that in turn switches on catabolic pathways. Moreover, metformin increases lipolysis and beta-oxidation in white adipose tissue, thereby reducing the triglyceride stores. The uncoupling proteins (UCPs) are transporters that lower the efficiency of mitochondrial oxidative phosphorylation. UCP2 is thought to protect against oxidative stress...
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