Diabetes
New diabetes study results reported from National Institute of Diabetes and Digestive and Kidney Diseases
Published in Obesity and Diabetes Week, January 19th, 2009
"Humans with functional variants in the melanocortin 4 receptor (MC4R) are obese, hyperpliagic, and hyperinsulinemic but have been reported to have no difference in energy expenditure. We investigated the association of two MC4R variants, Arg165Gln (R165Q) and A insertion at nucleotide 100 (NT100), with adiposity in 310741 full-heritage Pima Indians, a subset of whom had metabolic measures including 24-h energy expenditure (n = 252) and resting metabolic rate (RMR) (n = 364)," investigators in the United States report.
"Among the 3,074 subjects, 43 were heterozygous for R165Q and 14 for NT100 (frequency = 0.007 and 0.002). Mean (+/-SD) BMI Was higher among subjects with...
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