Obesity and Diabetes

New research on obesity and diabetes from University of Texas summarized

Published in Obesity and Diabetes Week, February 9th, 2009

"Impairments in adiponectin multimerization lead to defects in adiponectin secretion and function and are associated with diabetes, yet the underlying mechanisms remain largely unknown. We have identified an adiponectin-interacting protein, previously named GST-kappa, by yeast 2-hybrid screening," scientists in the United States report.

"The adiponectin-interacting protein contains 2 thioredoxin domains and has very little sequence similarity to other GST isoforms. However, this protein shares high sequence and secondary structure homology to bacterial disulfide-bond A oxidoreductase (DsbA) and is thus renamed DsbA-like protein (DsbA-L). DsbA-L is highly expressed in...

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Source: Obesity and Diabetes Week (2009-02-09)

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