Gene Therapy
Studies from R.X. Wang and co-authors have provided new information about gene therapy
Published in Obesity and Diabetes Week, February 9th, 2009
According to a study from Beijing, People's Republic of China, "Our previous studies demonstrated that lipopolysaccharide (LPS)-stimulated splenocytes, retrovirally transduced with a glutamate decarboxylate 65 (GAD) and immunoglobulin G (IgG) fusion construct, can protect non-obese diabetic (NOD) mice from diabetes by inducing GAD-specific tolerance, and also that there are increased numbers of CD4(+) regulatory T cells (Tregs) in GAD-IgG-treated NOD mice. However, little is known about the role of CD8(+) Tregs in GAD-IgG gene-transferred tolerance induction in NOD mice."
"Here, we found that GAD-IgG-transduced splenocytes induced an increase in the number of CD8(+)...
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