Diabetes

Research reports from Karolinska University provide new insights into diabetes

Published in Obesity and Diabetes Week, February 23rd, 2009

"The pancreatic beta cell response to cytokines is crucial for the development of type 1 diabetes in the NOD mouse. For example, beta cell production of suppressor of cytokine signalling-1 (SOCS-1) protects against diabetes," scientists in Huddinge, Sweden report.

"This finding and other recent studies indicated that cytokine-stressed beta cells might contribute to disease progression by affecting the pancreatic lymphocyte infiltrate. The aim of this study was to provide insight into how the beta cell influences the pancreas-infiltrating T cell repertoire. Lymphocytes isolated from Socs1-transgenic (tg) and non-tg NOD mice were analysed by flow cytometry. mRNA and...

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Source: Obesity and Diabetes Week (2009-02-23)

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