Obesity and Diabetes

Researchers from Wake Forest University discuss findings in obesity and diabetes

Published in Obesity and Diabetes Week, March 9th, 2009

According to recent research from the United States, "Pancreatic neuronal changes associated with beta cell loss in type 1 diabetes mellitus are complex, involving, in part, parasympathetic mechanisms to compensate for preclinical hyperglycemia. The parasympathetic neurotransmitter acetylcholine (ACh) mediates insulin release via M3 muscarinic receptors on islet beta cells."

"The vesicular ACh transporter (VAChT) receptor has been shown to be a useful marker of cholinergic activity in vivo. The positron emission tomography (PET) radiotracer (+)-4-[F-18]fluorobenzyltrozamicol ([F-18]FBT) binds to the VAChT receptor on presynaptic cholinergic neurons and can be quantified...

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Source: Obesity and Diabetes Week (2009-03-09)

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