Ohio State University
Researchers uncover 'obesity gene' involved in weight gain response to high-fat diet
Published in Obesity and Diabetes Week, March 23rd, 2009
The finding in an animal study suggests that blocking this gene could one day be a therapeutic strategy to reduce diet-related obesity and associated disorders, such as diabetes and liver damage, in humans.
The researchers found that a diet rich in fat induced production of this gene, called protein kinase C beta (PKC beta), in the fat cells of mice. These mice rapidly gained weight while eating a high-fat diet for 12 weeks.
On the other hand, mice genetically engineered to lack PKC beta gained relatively little weight and...
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