Corticosteroid
Studies in the area of corticosteroid reported from L. Gao and co-researchers
Published in Obesity and Diabetes Week, March 30th, 2009
According to recent research from the United States, "Abnormal elevation of 11 beta-HSD1 activities in tissues, such as fat and brain, may contribute to the development of the abdominal obesity and Alzheimer disease, and the inhibition of 11 beta-HSD1 might be beneficial to the management of these diseases. To assess the effects of pharmacologic inhibitors of 11 beta-HSD1, we developed a fast LC/MS/MS method to quantify corticosteroids in minced tissue samples in the presence of 11 beta-HSD substrates."
"The novel on-line SPE-LC/MS/MS method was developed with dual binary gradient and a throughput of 4.5 min/sample. A total of six corticosteroids (cortisol. cortisone,...
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