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Diabetes

Scientists at University of British Columbia target diabetes

Published in Obesity and Diabetes Week, May 25th, 2009

"Gwiazda KS, Yang TL, Lin Y, Johnson JD. Effects of palmitate on ER and cytosolic Ca2+ homeostasis in beta-cells," scientists writing in the American Journal of Physiology - Endocrinology and Metabolism report.

"Am J Physiol Endocrinol Metab 296: E690-E701, 2009. First published January 13, 2009; doi:10.1152/ajpendo.90525.2008.-There are strong links between obesity, elevated free fatty acids, and type 2 diabetes. Specifically, the saturated fatty acid palmitate has pleiotropic effects on beta-cell function and survival. In the present study, we sought to determine the mechanism by which palmitate affects intracellular Ca2+, and in particular the role of the...

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