Gastroenterology

Research from University of Illinois in gastroenterology provides new insights

Published in Obesity and Diabetes Week, June 29th, 2009

According to a study from the United States, "Small Heterodimer Partner (SHP) inhibits activities of numerous transcription factors involved in diverse biological pathways. As an important metabolic regulator, SHP plays a key role in maintaining cholesterol and bile acid homeostasis by inhibiting cholesterol conversion to bile acids."

"While SHP gene induction by increased bile acids is well established, whether SHP activity is also modulated remains unknown. Here, we report surprising findings that SHP is a rapidly degraded protein via the ubiquitin-proteasomal pathway and that bile acids or bile acid-induced intestinal fibroblast growth factor 19 (FGF19) increases...

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Source: Obesity and Diabetes Week (2009-06-29)

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