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Melanoma

Washington University reports research in melanoma

Published in Obesity and Diabetes Week, July 6th, 2009

"Immunodeficient mice serve as critical hosts for transplantation of xenogeneic cells for in vivo analysis of various biological processes. Because investigators typically select one or two immunodeficient mouse strains as recipients, no comprehensive study has been published documenting differences in human tumor engraftment," investigators in the United States report.

"Taking advantage of the increased metastatic potential of RhoC-expressing human (A375) melanoma cells, we evaluate four immunodeficient mouse strains: severe combined immunodeficiency (scid), nonobese diabetic (NOD)-scid, NOD-scid beta 2m(null), and NOD-scid IL2R gamma(null) as xenograft tumor...

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