Obesity & Diabetes Week
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Adipose Tissue
New adipose tissue research reported from S.P. Samarasinghe and co-authors
July 6th, 2009
"Peroxisome proliferator-activated receptor gamma (PPAR gamma) acts as a ligand-dependent transcription factor with a key role in mediating adipocyte differentiation and insulin sensitivity. Recently, we and others have shown that PPAR. recruits the nuclear corepressors NCoR and silencing mediator for retinoid and thyroid hormone receptors (SMRT) to modulate adipogenesis," scientists in the United States report. "While the synthetic ligands for PPAR gamma, the thiazolidinediones (TZD), are widely used in the treatment of type 2 diabetes mellitus, the biologically relevant endogenous PPAR gamma ligand involved in adipogenesis remains unidentified. To further understand...
Source: Obesity & Diabetes Week (2009-07-06)
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