Obesity and Diabetes

New data from University of Pittsburgh illuminate research in obesity and diabetes

Published in Obesity and Diabetes Week, August 31st, 2009

According to a study from the United States, "Skeletal muscle fat is greater in African ancestry individuals compared with whites, is associated with diabetes, and is a heritable polygenic trait. However, specific genetic factors contributing to skeletal muscle fat in humans remain to be defined."

"Muscle carnitine palmitoyltransferase-1B (CPT1B) is a key enzyme in the regulation of skeletal muscle mitochondrial beta-oxidation of long-chain fatty acids, and as such is a reasonable biological candidate gene for skeletal muscle fat accumulation. Therefore, we examined the association of three nonsynonymous coding variants in CPT1B (G531L, I66V, and S427C; a fourth, A320G,...

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Source: Obesity and Diabetes Week (2009-08-31)

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