Obesity and Diabetes

New obesity and diabetes research from University of Bremen outlined

Published in Obesity and Diabetes Week, August 31st, 2009

"In obesity, beta cells activate compensatory mechanisms to adapt to the higher insulin demand. Interleukin-1 receptor antagonist (IL-1Ra) prevents obesity-induced hyperglycaemia and is a potent target for the treatment of diabetes, but the mechanisms of its secretion and regulation in obesity are unknown," scientists writing in the journal Diabetologia report.

"In the present study, we hypothesise the regulation of IL-1Ra secretion by purinergic P2X(7) receptors in islets. Production and regulation of P2X(7) were studied in pancreatic sections from lean and obese diabetic patients, non-diabetic controls and in isolated islets. IL-1Ra, IL-1 beta and insulin...

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Source: Obesity and Diabetes Week (2009-08-31)

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