Genetics & Genomics
Study results from R. Cagliani et al provide new insights into genetics & genomics
Published in Obesity and Diabetes Week, August 31st, 2009
"In humans, three genes-ADRB1, ADRB2 and ADRB3-encode beta-adrenoreceptors (ADRB); these molecules mediate the action of catecholamines in multiple tissues and play pivotal roles in cardiovascular, respiratory, metabolic, and immunological functions. Genetic variants in ADRB genes have been associated with widespread diseases and conditions, but inconsistent results have often been obtained," scientists in Bosisio Parini, Italy report.
"Here, we addressed the recent evolutionary history of ADRB genes in human populations. Although ADRB1 is neutrally evolving, most tests rejected neutral evolution for ADRB2 in European, African, and Asian population samples. Analysis of...
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