Published in Obesity and Diabetes Week, September 7th, 2009
"Epidermal growth factor (EGF) stimulates IGF-I synthesis in vitro. We examined the effect of IGF-I and EGF treatment, separately or in combination, on the vulnerability of steatotic livers to I/R. Our results indicated that I/R impaired IGF-I synthesis only in steatotic livers. Only when a high dose of IGF-I (400 mu g/kg) was given to obese animals did they show high circulating IGF-I: IGFBP levels, increased hepatic IGF-I levels, and protection...
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