Obesity and Diabetes

Reports from Baylor College of Medicine, College of Medicine describe recent advances in obesity and diabetes

Published in Obesity and Diabetes Week, September 21st, 2009

According to a study from the United States, "Activin-beta A and activin-beta B (encoded by Inhba and Inhbb genes, respectively) are closely related TGF-beta superfamily members that participate in a variety of biological processes. We previously generated mice with an insertion allele at the Inhba locus, Inhba(BK)."

"In this allele, the sequence encoding the Inhba mature domain is replaced with that of Inhbb, rendering the gene product functionally hypomorphic. Homozygous (Inhba(BK/BK)) and hemizygous (Inhba(BK/-)) mice are smaller and leaner than their wild-type littermates, and many tissues are disproportionately small relative to total body weight. To determine the...

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Source: Obesity and Diabetes Week (2009-09-21)

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