Obesity and Diabetes

Research by K. Kos and colleagues in obesity and diabetes provides new insights

Published in Obesity and Diabetes Week, September 21st, 2009

According to recent research from Liverpool, the United Kingdom, "Matricellular Secreted Protein, Acidic and Rich in Cysteine (SPARC), originally discovered in bone as osteonectin, is a mediator of collagen deposition and promotes fibrosis. Adipose tissue collagen has recently been found to be linked with metabolic dysregulation."

"Therefore, we tested the hypothesis that SPARC in human adipose tissue is influenced by glucose metabolism and adipokines. Serum and adipose tissue biopsies were obtained from morbidly obese nondiabetic subjects undergoing bariatric surgery and lean control subjects for analysis of metabolic markers, SPARC, and various cytokines (RT-PCR)....

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Source: Obesity and Diabetes Week (2009-09-21)

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