Obesity
Studies from I. Kalnina et al have provided new data on obesity
Published in Obesity and Diabetes Week, September 21st, 2009
"The agouti related protein (AGRP) is an endogenous antagonist of the melanocortin 4 receptor and is one of the most potent orexigenic factors. The aim of the present study was to assess the genetic variability of AGRP gene and investigate whether the previously reported SNP rs5030980 and the rs11575892, a SNP that so far has not been studied with respect to obesity is associated with increased body mass index (BMI)," scientists in Riga, Latvia report.
"We determined the complete sequence of the AGRP gene and upstream promoter region in 95 patients with severe obesity (BMI > 35 kg/m(2)). Three polymorphisms were identified: silent mutation c. 123G > A (rs34123523)...
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