Fibrosis

Research on fibrosis described by scientists at University of Texas

Published in Obesity and Diabetes Week, September 28th, 2009

According to recent research published in the journal Molecular and Cellular Biology, "Adipose tissue can undergo rapid expansion during times of excess caloric intake. Like a rapidly expanding tumor mass, obese adipose tissue becomes hypoxic due to the inability of the vasculature to keep pace with tissue growth."

"Consequently, during the early stages of obesity, hypoxic conditions cause an increase in the level of hypoxia-inducible factor 1 alpha (HIF1 alpha) expression. Using a transgenic model of overexpression of a constitutively active form of HIF1 alpha, we determined that HIF1 alpha fails to induce the expected proangiogenic response. In contrast, we...

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Source: Obesity and Diabetes Week (2009-09-28)

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