Obesity and Diabetes

Investigators at Medical College of Georgia, Medical College publish new data on obesity and diabetes

Published in Obesity and Diabetes Week, October 12th, 2009

"Obesity causes hypertension and sympathoactivation, a process proposed to be mediated by leptin. Protein tyrosine phosphatase 1B (PTP1B), a major new pharmaceutical target in the treatment of obesity and type II diabetes mellitus, constrains the metabolic actions of leptin, but the extent to which PTP1B regulates its cardiovascular effects is unclear," investigators in the United States report.

"This study examined the hypothesis that PTP1B is a negative regulator of the cardiovascular effects of leptin. PTP1B knockout mice had lower body fat but higher mean arterial pressure (116 +/- 5 versus 105 +/- 5 mm Hg, P< 0.05) than controls. Leptin infusion produced a...

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Source: Obesity and Diabetes Week (2009-10-12)

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