Obesity and Diabetes

New findings in obesity and diabetes described by G.J. Chen and co-researchers

Published in Obesity and Diabetes Week, October 19th, 2009

According to a study from Beijing, People's Republic of China, "Recently, the anti-CD3 antibody has been shown to be a promising candidate for the efficient treatment of overt autoimmunity. However, the mechanisms underlying this effect remain unclear."

"Our previous studies demonstrated that natural killer (NK)T cells and transforming growth factor (TGF)-beta were key elements in anti-CD3 F(ab')(2)-mediated re-establishment of glucose homeostasis and restoration of self tolerance to islets in type 1 diabetes. In this report, we further investigate the regulatory pathways involved, especially the cellular source of TGF-beta production. The treatment of new-onset...

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Source: Obesity and Diabetes Week (2009-10-19)

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