Obesity and Diabetes
Reports summarize obesity and diabetes study results from F.C. Chou and co-researchers
Published in Obesity and Diabetes Week, November 9th, 2009
"Pancreatic islet transplantation is considered an appropriate treatment to achieve insulin independence in type I diabetic patients. However, islet isolation and transplantation-induced oxidative stress and autoimmune-mediated destruction are still the major obstacles to the long-term survival of graft islets in this potential therapy," scientists writing in the Journal of Biomedical Science report.
"To protect islet grafts from inflammatory damage and prolong their survival, we transduced islets with an antioxidative gene thioredoxin (TRX) using a lentiviral vector before transplantation. We hypothesized that the overexpression of TRX in islets would prolong...
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