Obesity & Diabetes Week
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Retinoblastoma
New findings from University of Naples in the area of retinoblastoma described
November 9th, 2009
"It is generally accepted that the regulation of adipogenesis prevents obesity. However, the mechanisms controlling adipogenesis have not been completely defined," investigators in Naples, Italy report. "We have previously demonstrated that HMGA1 proteins play a critical role in adipogenesis. In fact, suppression of HMGA1 protein synthesis by antisense technology dramatically increased growth rate and impaired adipocyte differentiation in 3T3-L1 cells. Furthermore, we showed that HMGA1 strongly potentiates the capacity of the CCAAT/enhancer-binding protein beta (C/EBP beta) transcriptional factor to transactivate the leptin promoter, an adipocytic-specific promoter. In...
Source: Obesity & Diabetes Week (2009-11-09)
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