Catecholamin

New catecholamin study findings have been reported from University of California, Medical Department

Published in Obesity and Diabetes Week, December 7th, 2009

"Chromogranin A (CHGA/Chga), a proprotein, widely distributed in endocrine and neuroendocrine tissues (not expressed in muscle, liver, and adipose tissues), generates at least four bioactive peptides. One of those peptides, pancreastatin (PST), has been reported to interfere with insulin action," scientists writing in the Journal of Biological Chemistry report.

"We generated a Chga knock-out (KO) mouse by the targeted deletion of the Chga gene in neuroendocrine tissues. KO mice displayed hypertension, higher plasma catecholamine, and adipokine levels and lower IL-6 and lipid levels compared with wild type mice. Liver glycogen content was elevated, but the nitric...

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Source: Obesity and Diabetes Week (2009-12-07)

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