Research findings, 'The nuclear cofactor DOR regulates autophagy in mammalian and Drosophila cells,' are discussed in a new report. "The regulation of autophagy in metazoans is only partly understood, and there is a need to identify the proteins that control this process. The diabetes-and obesity-regulated gene (DOR), a recently reported nuclear cofactor of thyroid hormone receptors, is expressed abundantly in metabolically active tissues such as muscle," scientists in Barcelona, Spain report.
"Here, we show that DOR shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation. We...
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