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Acute Pancreatitis Cell Biology

Reports outline acute pancreatitis cell biology study findings from University of Illinois

Published in Obesity and Diabetes Week, March 29th, 2010

Current study results from the report, 'Effect of diet-induced obesity on acute pancreatitis induced by administration of interleukin-12 plus interleukin-18 in mice,' have been published. "Obesity is associated with increased severity of acute pancreatitis (AP). We recently developed a model of AP induced by administration of interleukin (IL)-12+IL-18, two cytokines that are elevated in patients with AP," scientists in the United States report.

"In this model, severe AP develops in obese leptin-deficient ob/ob mice compared to lean littermates. In the present report, we evaluated the pancreatic response of diet-induced obesity (DIO) mice to IL-12+IL-18. Body weight loss...

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