Atherosclerosis

Research from J. Ishiyama and colleagues has provided new data on atherosclerosis

Published in Obesity and Diabetes Week, April 12th, 2010

According to a study from Tochigi, Japan, "Elevated levels of nonesterified fatty acids (NEFA) in obesity and type 2 diabetes may contribute to the development of atherosclerosis. Therefore, we examined whether NEFA could regulate expression of scavenger receptors responsible for uptake of oxidized LDL (oxLDL) in macrophages, a critical step in atherogenesis."

"Expression level of scavenger receptors in NEFA-treated macrophage-like THP-1 and Raw264.7 cells were analyzed by real-time PCR. Palmitic acid showed the greatest enhancement of expression of lectin-like oxidized LDL receptor (LOX-1) among 7 NEFA examined (4 saturated and 3 unsaturated fatty acids). Upregulation...

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Source: Obesity and Diabetes Week (2010-04-12)

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