Post-Translational Protein Processing
Scientists at Harvard University, Division of Endocrinology discuss research in post-translational protein processing
Published in Obesity and Diabetes Week, May 10th, 2010
Scientists discuss in 'The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation' new findings in post-translational protein processing. According to recent research published in the journal Nature Medicine, "Despite the fact that X-box binding protein-1 (XBP-1) is one of the main regulators of the unfolded protein response (UPR), the modulators of XBP-1 are poorly understood. Here, we show that the regulatory subunits of phosphotidyl inositol 3-kinase (PI3K), p85alpha (encoded by Pik3r1) and p85beta (encoded by Pik3r2) form heterodimers that are disrupted by insulin treatment."
"This disruption of...
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