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Hormones

Research on hormones detailed by scientists at Kochi University

Published in Obesity and Diabetes Week, May 24th, 2010

A new study, 'Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription,' is now available. "Both glucocorticoid and insulin are known to have an anabolic effect on lipogenesis. Acetyl-CoA, an intermediate product of glycolysis, is supplied for fatty acid synthesis when carbohydrate intake is sufficient," researchers in Japan report.

"Acetyl-CoA carboxylase (ACC), consisting of two isoenzymes ACC1 and ACC2, mediates the conversion from acetyl-CoA to malonyl-CoA, and thus plays a key role for the regulation of lipogenesis. In this study, we surveyed the effects of glucocorticoid and insulin on the transcriptional activity of the alternative promoters of...

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