Pattern Recognition Receptors

Research on pattern recognition receptors detailed by O. Poulaingodefroy and co-authors

Published in Obesity and Diabetes Week, May 31st, 2010

According to recent research from Lille, France, "It was recently demonstrated that TLR4 activation via dietary lipids triggers inflammatory pathway and alters insulin responsiveness in the fat tissue during obesity. Here, we question whether other TLR family members could participate in the TLR-mediated inflammatory processes occurring in the obese adipose tissue."

"We thus studied the expression of TLR1, TLR2, TLR4, and TLR6 in adipose tissue. These receptors are expressed in omental and subcutaneous human fat tissue, the expression being higher in the omental tissue, independently of the metabolic status of the subject. We demonstrated a correlation of TLRs...

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Source: Obesity and Diabetes Week (2010-05-31)

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