Diabetes

Data from National Institutes of Health Advance Knowledge in Diabetes

Published in Obesity and Diabetes Week, February 28th, 2011

2011 FEB 28 -- According to a study from the United States, "The nuclear receptor TAK1/TR4/NR2C2 is expressed in several tissues that are important in the control of energy homeostasis. In this study, we investigate whether TAK1 functions as a regulator of lipid and energy homeostasis and has a role in metabolic syndrome."

"We generated TAK1-deficient (TAK1(-/-)) mice to study the function of TAK1 in the development of metabolic syndrome in aged mice and mice fed a high-fat diet (HFD). (Immuno)histochemical, biochemical, and gene expression profile analyses were performed to determine the effect of the loss of TAK1 expression on lipid homeostasis in liver...

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Source: Obesity and Diabetes Week (2011-02-28)

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