Neuropeptide Receptors

Merck Research Laboratories Publishes Research in Neuropeptide Receptors

Published in Obesity and Diabetes Week, May 2nd, 2011

2011 MAY 2 -- According to a study from Rahway, United States, "Bombesin receptor subtype-3 (BRS-3) is an orphan G-protein coupled receptor belonging to the subfamily of bombesin-like receptors."

"BRS-3 is implicated in the development of obesity and diabetes. We report here small-molecule agonists that are based on a 4-(alkylamino)pyridine-3-sulfonamide core," wrote M.M.C. Lo and colleagues, Merck Research Laboratories.

The researchers concluded: "We describe the discovery of 2a, which has mid-nanomolar potency, selectivity for human BRS-3 versus the other bombesin-like receptors, and good bioavailability."

Lo and...

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Source: Obesity and Diabetes Week (2011-05-02)

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