Diabetes

Findings from Sungkyunkwan University Provide New Insights into Diabetes

Published in Obesity and Diabetes Week, July 18th, 2011

2011 JUL 18 -- According to the authors of a study from Seoul, South Korea, "Diet-induced obesity (DIO) is linked to peripheral insulin resistance-a major predicament in type 2 diabetes. This study aims to identify the molecular mechanism by which DIO-triggered endoplasmic reticulum (ER) stress promotes hepatic insulin resistance in mouse models."

"C57BL/6 mice and primary hepatocytes were used to evaluate the role of LIPIN2 in ER stress-induced hepatic insulin resistance. Tunicamycin, thapsigargin, and lipopolysaccharide were used to invoke acute ER stress conditions. To promote chronic ER stress, mice were fed with a high-fat diet for 8-12 weeks. To...

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Source: Obesity and Diabetes Week (2011-07-18)

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