Obesity

New Findings from Merck in the Area of Obesity Published

Published in Obesity and Diabetes Week, September 5th, 2011

2011 SEP 5 -- "Antagonism of the glucagon receptor (GCGR) represents a potential approach for treating diabetes. Cpd-A, a potent and selective GCGR antagonist (GRA) was studied in preclinical models to assess its effects on alpha cells," scientists in Rahway, New Jersey report.

"Studies were conducted with Cpd-A to examine the effects on glucose-lowering efficacy, its effects in combination with a dipeptidyl peptidase-4 (DPP-4) inhibitor, and the extent and reversibility of alpha cell hypertrophy associated with GCGR antagonism in mouse models. Chronic treatment with Cpd-A resulted in effective and sustained glucose lowering in mouse models in which...

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Source: Obesity and Diabetes Week (2011-09-05)

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