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Amyotrophic Lateral Sclerosis

Blocking metabolic protein improves movement in animals with ALS

Published in Obesity and Diabetes Week, January 30th, 2012

2012 JAN 30 -- Washington, DC - Turning off a protein that helps cells balance energy increases animal mobility and reduces the death of nerve cells that control movement in animal models of amyotrophic lateral sclerosis (ALS), according to a study in the January 18 issue of The Journal of Neuroscience. The findings may one day guide new directions for the treatment of the progressive neurodegenerative disorder, for which there is currently no cure.

ALS is characterized by the breakdown of brain and spinal cord nerve cells that control muscles, eventually leading to weakness and death. In many neurodegenerative diseases, including ALS, nerve cells have...

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