General Science

Investigators at Sanofi-Aventis Research and Development Detail Research in General Science

Published in Obesity and Diabetes Week, February 13th, 2012

2012 FEB 13 -- According to the authors of recent research from Toulouse, France, "A critical early step in drug discovery is the screening of a chemical library. Typically, promising compounds are identified in a primary screen and then more fully characterized in a dose-response analysis with 7-10 data points per compound."

"Here, we describe a robust microfluidic approach that increases the number of data points to approximately 10,000 per compound. The system exploits Taylor-Aris dispersion to create concentration gradients, which are then segmented into picoliter microreactors by droplet-based microfluidics. The large number of data points results in...

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Source: Obesity and Diabetes Week (2012-02-13)

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